DSIP
Delta sleep-inducing peptide, a nonapeptide used in neuropeptide research.
Prepared to order · approx. 7 days + Royal Mail Tracked 24
SKU BP-DSIP-5 · ≥99% (see COA) · Lyophilised powder
DSIP overview
DSIP is a nonapeptide first isolated in the 1970s. It is supplied as a lyophilised solid for in-vitro research.
DSIP research background
Evidence status: Findings summarised here include small human studies with weak or inconsistent results, alongside older preclinical research; the physiological role of DSIP remains unresolved. They are not established effects in humans, have not been evaluated by the MHRA, and are provided for scientific context only. This product is supplied strictly for laboratory research and is not for human or veterinary use.
Established research
Peer-reviewed published findings, with referencesOverview & discovery history
- Delta sleep-inducing peptide (DSIP) is a nonapeptide isolated in 1977 by Schoenenberger, Monnier and colleagues from the cerebral venous blood of rabbits during electrically induced sleep [1]. Its structure was confirmed by synthesis [2].
- Several decades of research have not identified a gene, precursor or receptor for DSIP. A 2006 review described it as 'a still unresolved riddle' [3].
Chemical identity
Identity values are confirmed per lot on the certificate of analysis. Salt/counter-ion form (e.g. acetate or TFA) is stated on the COA where applicable.
Mechanisms investigated
Research areas & model types
Human clinical research status
- In a double-blind study in chronic insomnia, statistically significant effects were weak and partly attributable to changes in the placebo group; the authors concluded that short-term DSIP was not of therapeutic value [6]. An earlier study also found no significant differences from baseline or placebo for most measures [7].
- DSIP is not an approved medicine.
Safety observations reported in studies
- The older human studies did not report serious adverse events, but they were small and short.
Known limitations
- There is no identified gene, precursor or receptor [3].
- The literature is mostly from the 1970s–1990s.
Storage & handling for laboratory use
Store at −20 °C. Protect from light.
Store lyophilised material sealed at −20 °C or below, protected from light and moisture. Allow the vial to equilibrate to room temperature before opening to limit condensation.
- Allow the sealed vial to reach room temperature before opening to limit condensation.
- Any solutions should be prepared only for in-vitro laboratory work under your own validated protocol; aliquoting limits repeated freeze–thaw cycles.
- Handle with standard laboratory PPE in line with your risk assessment and the Safety Data Sheet (SDS). Britpep does not provide preparation or administration guidance.
Emerging & theoretical
Unconfirmed — hypotheses & ongoing researchThese are unconfirmed hypotheses and early-stage lines of enquiry, not established effects. Not evaluated by the MHRA. Not for human or veterinary use.
Hypotheses proposed by researchers
- Researchers have suggested that the DSIP-like activities may come from a related, as yet unidentified endogenous peptide, and that structurally similar peptides warrant study [3].
Open scientific questions
- Does DSIP exist as a defined endogenous mediator?
Preprints: none included (no relevant preprint could be verified). Anecdotal, user-reported or social-media material is deliberately excluded.
References
- Schoenenberger GA, Monnier M. Characterization of a delta-electroencephalogram (-sleep)-inducing peptide. Proc Natl Acad Sci U S A. 1977. PubMed 265572 · doi:10.1073/pnas.74.3.1282
- Monnier M, Dudler L, Gächter R et al.. The delta sleep inducing peptide (DSIP). Comparative properties of the original and synthetic nonapeptide. Experientia. 1977. PubMed 862769 · doi:10.1007/BF01922266
- Kovalzon VM, Strekalova TV. Delta sleep-inducing peptide (DSIP): a still unresolved riddle. J Neurochem. 2006. PubMed 16539679 · doi:10.1111/j.1471-4159.2006.03693.x
- Graf MV, Kastin AJ. Delta-sleep-inducing peptide (DSIP): a review. Neurosci Biobehav Rev. 1984. PubMed 6145137 · doi:10.1016/0149-7634(84)90022-8
- Graf MV, Kastin AJ. Delta-sleep-inducing peptide (DSIP): an update. Peptides. 1986. PubMed 3550726 · doi:10.1016/0196-9781(86)90148-8
- Bes F, Hofman W, Schuur J et al.. Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients. A double-blind study. Neuropsychobiology. 1992. PubMed 1299794 · doi:10.1159/000118919
- Monti JM, Debellis J, Alterwain P et al.. Study of delta sleep-inducing peptide efficacy in improving sleep on short-term administration to chronic insomniacs. Int J Clin Pharmacol Res. 1987. PubMed 3583493
- Tukhovskaya EA, Ismailova AM, Shaykhutdinova ER et al.. Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke. Molecules. 2021. PubMed 34500605 · doi:10.3390/molecules26175173
Every reference was checked against PubMed (NCBI) before publication. Summaries describe published research only and are not claims of any effect in humans or animals.
Certificates of analysis
[No batch COA published yet. The certificate for each lot will be listed here and in the COA checker before release.]
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